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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 24, 1994 - Issue 2
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Original Articles

One-Pot Synthesis of Pyrimidine-5-Carboxaldehyde and Ethyl Pyrimidine-5-Carboxylate by Utilizing Pyrimidin-5-yl-Lithium

Taikyun Rho Department of Medicinal Chemistry Center for Drug Design and Development, College of Pharmacy, The University of Toledo, Toledo, Ohio, 43606-3390
&
Yahaya F. Abuh Department of Medicinal Chemistry Center for Drug Design and Development, College of Pharmacy, The University of Toledo, Toledo, Ohio, 43606-3390
Pages 253-256 | Received 15 Jul 1993, Published online: 23 Sep 2006
 
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Abstract

Pyrimidine-5-carboxaldehyde was prepared in a one-pot reaction from 5-bromo-pyrimidine via metal halogen exchange. Pyrimidin-5-yl-lithium reacted with formate ester and ethyl cyanoformate, forming respectively the aldehyde and carboxy ethyl ester.

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