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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 1
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Original Articles

Pictet-Spengler Cyclization of 3,3-Diphenylalanine (DIP) (III), Synthesis of Optically Pure 1,2,3,4-Tetrahydro-4-phenyl-3-isoquinolinecarboxylic Acids, Novel α-Amino Acids for Peptides of Biological Interest

Huai G. Chen Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA
&
O. P. Goel Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA
Pages 49-56 | Received 16 May 1994, Published online: 23 Sep 2006
 
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Abstract

All four isomers of 1,2,3,4-tetrahydro-4-phenyl-3-isoquinolinecarboxylic acid have been synthesized in highoptical purity for the synthesis of peptides of biological interest.

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