The In Situ Generation and Use of Iodomethyllithium for the One-Carbon Homologation of Boronic Esters and Epoxide Formation from Carbonyl Compounds

Abstract

Iodomethyllithium is shown to be an effective reagent for the one-carbon homologation of oxygenated boronic esters. The use of iodomethyllithium for the preparation of pinacol iodomethaneboronate and for the synthesis of epoxides from carbonyl compounds is also discussed.