Synthesis of 1, 2, 3, 9-Tetrahydro-7-bromo-6-hydroxy-5-methoxypyrrolo-[2, 1-b]-quinazoline: A New Analog of Deoxyvasicine

Abstract

A new deoxyvasicine analog (9) was synthesized by condensation of 2-amino-5-bromovanillin (6) with 4-aminobutyraldehyde (7) in phosphate buffer (pH 5.8) followed by hydrogenation of the resulting quinazolinium complex (8) at 65[ddot]C in presence of 5% palladium-on-barium sulfate.