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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 24
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Original Articles

A Novel, Efficient Synthesis of 3,3-Dimethylindoline

T. W. Ramsay Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW
,
G. R. Slater Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW
,
P. Smith Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW
&
SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW
Pages 4029-4033 | Received 25 Apr 1995, Published online: 23 Sep 2006
 
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Abstract

The Lewis acid mediated cyclisation of N-methallylacetanilide, followed by hydrolysis to give 3,3-dimethylindoline in excellent yield is described.

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