Ceric Ammonium Nitrate in Organic Synthesis III. A Facile Synthesis of Methoxylated 3, 4 Dihydroisoquinolinium Nitrates

Abstract

A mild and efficient method for the synthesis of 3, 4-dihydroisoquinolinium salts, key intermediates for the preparation of isoquinoline alkaloïds, by an oxidation of N-methyl-1, 2, 3, 4-tetrahydroisoquinolines using ceric ammonium nitrate (CAN) is described.