Synthesis of Thiols via Palladium Catalyzed Methanolysis of Thioacetates with Borohydride Exchange Resin

Abstract

Various thiols are prepared quantitatively from the corresponding thioacetates via Pd catalyzed methanolysis with borohydride exchange resin under a mild and neutral conditions. One-pot synthesis of thiols from alkyl halides through the formation of alkyl thioacetates using thioacetate exchange resin followed by methanolysis is also described.