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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 18
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Original Articles

Synthesis of Unsymmetrically Substituted α-Aminoalkylphosphonate Esters

Robert M. Moriarty Steroids, Ltd., 2201 W. Campbell Park Dr., Chicago, IL, 60612; University of Illinois at Chicago, Department of Chemistry, Chicago, IL, 60607
,
Kaiming Liu Steroids, Ltd., 2201 W. Campbell Park Dr., Chicago, IL, 60612
,
Hui Zhuang University of Illinois at Chicago, Department of Chemistry, Chicago, IL, 60607
,
David Lenz USAMRICD, Aberdeen Proving Ground., MD, 21010
,
Alan Brimfield USAMRICD, Aberdeen Proving Ground., MD, 21010
&
Chizhong Xia University of Illinois at Chicago, Department of Chemistry, Chicago, IL, 60607
Pages 2763-2773 | Received 13 Feb 1995, Published online: 16 Feb 2007
 
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Abstract

The title compounds were designed as haptens for production of monoclonal antibodies as potential catalysts for phosphoryl transfer reactions of phosphates and phosphonates. These haptens conform to the “bait and switch” model.

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