A New, Simple Procedure for the Preparation of 8-Methoxy-2-Tetralone

Sunkyung Lee Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907

Stewart P. Frescas Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907

David E. Nichols Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907

Abstract

8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bromide in the presence of an ester as a co-catalyst, and ketone deprotection.

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A New, Simple Procedure for the Preparation of 8-Methoxy-2-Tetralone

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A New, Simple Procedure for the Preparation of 8-Methoxy-2-Tetralone

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