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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 7
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Original Articles

The Conversion of Carboxylic Acids into Amides via NCS/Triphenylphosphine

Pages 959-968 | Received 31 Aug 1994, Published online: 23 Sep 2006
 

Abstract

Amides can be generated in very high yields under mild conditions from the corresponding carboxylic acid and amine in the presence of equivalent amounts of triphenylphosphine and N-halosuccinimides, e.g., NCS or NBS.

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