A Novel Route to N-Styrylamides

A. R. Katritzky Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA

A. V. Ignatchenko Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA

H. Lang Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA

Abstract

A general synthesis of N-styrylamides starting from amides and phenylacetaldehyde is described. Condensation of the amide, aldehyde and benzotriazole affords N-(1-benzotriazol-l-yl-2-phenylethyl)amides 2 from which the benzotriazole molecule is smoothly eliminated.

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A Novel Route to N-Styrylamides

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A Novel Route to N-Styrylamides

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