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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 8
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Original Articles

Synthesis of R- and S- Fluoxetine, Norfluoxetine and Related Compounds from Styrene Oxide

David Mitchell Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, 46285
&
Thomas M. Koenig Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, 46285
Pages 1231-1238 | Received 13 Oct 1994, Published online: 23 Sep 2006
 
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Abstract

A facile, high yield synthesis of R—or S—fluoxetine and norfluoxetine is described. This synthetic route utilizes readily available starting materials.

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