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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 9
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Original Articles

Synthesis of Cytotoxic Pyrrolo[1,2-a]-benzimidazol-1-ones

John A. Hadfield CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 9BX
,
Vasilios H. Pavlidis Department of Applied Sciences, De Montfort University Leicester, The Gateway, Leicester, LE1 9BH
&
John R. A. Roffey Department of Applied Sciences, De Montfort University Leicester, The Gateway, Leicester, LE1 9BH
Pages 1319-1329 | Received 16 Sep 1994, Published online: 23 Sep 2006
 
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Abstract

Several pyrrolo[1,2-a]benzimidazol-1-ones have been synthesised and shown to be cytotoxic to two mammalian cell lines. A synthesis of the novel ring system isoindolo[1,2-a]benzimidazol-1-one is described.

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