Simple Phase Transfer Catalytic Method for α-Methoxylation of Sterically Hindered Ketones

E. Abele Latvian Institute of Organic Synthesis, Aizkraukles, 21, Riga, LV-1006, Latvia

K. Rubina Latvian Institute of Organic Synthesis, Aizkraukles, 21, Riga, LV-1006, Latvia

M. Shymanska Latvian Institute of Organic Synthesis, Aizkraukles, 21, Riga, LV-1006, Latvia

E. Lukevics Latvian Institute of Organic Synthesis, Aizkraukles, 21, Riga, LV-1006, Latvia

Abstract

Reactions of sterically hindered ketones of ArylCOCHR¹R² type (R¹, R² = Me, Et, Ph) with carbon tetrachloride and methyl iodide in the presence of solid KOH and 18-crown-6 afford the corresponding α methoxyketones [ArylCOC(OMe)R¹R²] in one-pot process in 30–67% yields.

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Simple Phase Transfer Catalytic Method for α-Methoxylation of Sterically Hindered Ketones

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Simple Phase Transfer Catalytic Method for α-Methoxylation of Sterically Hindered Ketones

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