A Practical Synthesis of Hydroxyl-N-tosylcyclams via Cyclization of 1,3-Dichloro-2-propanol with Disodium Di(Poly)-N-Tosylamides

Minghu Wu Department of Chemistry, Xianning Normal College Xianning, 437005, P. R. of China

Guopeng Cheng Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. of China

Yongbing He Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. of China

Chengtai Wu Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. of China

Abstract

Cyclization of 1, 3-dichloro-2-propanol with di(poly)-N-to-sylamides in the presence of sodium ethoxide in ethanol under reflux conditions gave hydroxyl-N-tosylcyclams in moderate yields. This procedure presents a practical and facile method for synthesis of [1+1] all-nitrogen cyclams.

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A Practical Synthesis of Hydroxyl-N-tosylcyclams via Cyclization of 1,3-Dichloro-2-propanol with Disodium Di(Poly)-N-Tosylamides

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A Practical Synthesis of Hydroxyl-N-tosylcyclams via Cyclization of 1,3-Dichloro-2-propanol with Disodium Di(Poly)-N-Tosylamides

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