Synthesis of Lipophilic 3-Hydroxy-2-methyl-4-pyridinone Derivatives

G. Liu Division of Radiobiology, School of Medicine, University of Utah, Bldg 585, Salt Lake City, UT, 84112, U.S.A.

S. C. Miller Division of Radiobiology, School of Medicine, University of Utah, Bldg 585, Salt Lake City, UT, 84112, U.S.A.

F. W. Bruenger Division of Radiobiology, School of Medicine, University of Utah, Bldg 585, Salt Lake City, UT, 84112, U.S.A.

Abstract

Hydrophilic 2- hydroxy-3-methyl-4-pyridinone derivatives were acylated with either long chain acid chlorides or with 1,3,5-benzenetricarbonyl trichloride. The products are either partially lipophilic, bidentatate or hexadentate chelators that form strong 3:1 and 1:1 complexes, respectively, with Fe (III).

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Synthesis of Lipophilic 3-Hydroxy-2-methyl-4-pyridinone Derivatives

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Synthesis of Lipophilic 3-Hydroxy-2-methyl-4-pyridinone Derivatives

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