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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 20
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Original Articles

An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-Tetrahydroisoquinoline

H. G. Selnick Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, 19486
,
G. R. Smith Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, 19486
&
A. J. Tebben Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, 19486
Pages 3255-3261 | Received 16 Mar 1995, Published online: 23 Sep 2006
 
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Abstract

A short synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline is presented. The key step is an improved method of aryl triflate cyanation employing zinc(II)cyanide as the cyanide source.

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