A Convenient Synthesis Of Isopropyl Ethers from Secondary Alcohols

Thierry Le Diguarher Department of Medicinal Chemistry, Institut de Recherches SERVIER, 11 Rue des Moulineaux, Suresnes, 92150, FRANCE

David C. Billington Department of Medicinal Chemistry, Institut de Recherches SERVIER, 11 Rue des Moulineaux, Suresnes, 92150, FRANCE

Gilbert Dorey Department of Medicinal Chemistry, Institut de Recherches SERVIER, 11 Rue des Moulineaux, Suresnes, 92150, FRANCE

Abstract

A convenient synthesis of isopropyl ethers from the corresponding secondary alcohols has been developed, involving acetate formation, conversion to the enol ether via an organotitanium reagent, and subsequent catalytic hydrogenation to the isopropyl ether.

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A Convenient Synthesis Of Isopropyl Ethers from Secondary Alcohols

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A Convenient Synthesis Of Isopropyl Ethers from Secondary Alcohols

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