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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 6
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Original Articles

Synthesis of 2-Fluoro- Acids, Esters, and Amides From Ã-Dicyanoepoxides

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Pages 1155-1161 | Received 18 Sep 1995, Published online: 21 Aug 2006
 

Abstract

The opening of Ã-dicyanoepoxides by pyridine polyhdrofluoride yields polymerisable 2-fluorocyanoformyls which may be kept intact when diluated in dichloromethane or ether. These intermediates react with nuclecophiles such as water, methanol or amines to give respectivly 2-fluoroacids, esters or amides.

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