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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 21
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Original Articles

Thermal Removal of Boc-Protecting Groups During Preparation of Open-Chain Polyamines

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Pages 3999-4004 | Received 19 May 1996, Published online: 23 Aug 2006
 

Abstract

Per-N-tosylated 3,8-diaza-1,10-decanediamine (9), 4,9-diaza-1,12-dodecanediamine (spermine) (10) and 3,6,9,14,17,20-hexaaza-1,22-docosanediamine (11) were prepared by treating mono-BOC-protected, per-N-tosylated 1,2-ethanediamine (5), 1,3-propanediamine (6) and triethylenetetraamine (7), respectively, with 1,4-dibromobutane and removing the BOC-protecting groups at 100–120 °C.

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