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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 13
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Original Articles

Regioselective Electrophilic Substitution of 2-Hydroxy and 2-Methoxy Substituted Acridines. Application to the Synthesis of Pyrido[2,3,4-mn]acridine

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Pages 2311-2324 | Received 10 Dec 1996, Published online: 22 Aug 2006
 

Abstract

The presence of a hydroxy or methoxy group in position 2 of acridine directs the electrophilic substitution by formaldehyde in methane sulfonic acid to position 1. This reactivity is applied to the synthesis of pyrido[2,3,4-m,n]acridine.

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