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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 10
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Original Articles

Opening of Glycidol with Phenols in Water Using Catalytic Amounts of Sodium Hydroxide: A Practical Synthesis of 3-Aryloxy-1,2-propanediols

Stephen Palermo Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
,
Liladhar Waykole Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
,
Kau-Ming Chen Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
,
Mahavir Prashad Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
,
Kapa Prasad Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
,
Oljan Repic Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
&
Thomas J. Blacklock Chemical Research & Development Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936
 show all
Pages 1757-1761 | Received 03 Dec 1996, Published online: 22 Aug 2006
 
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Abstract

A practical synthesis of enantiopure 3-aryloxy-1,2-propanediols by opening of (S)-glycidol with phenols under aqueous conditions using catalytic amounts of sodium hydroxide is described.

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