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Abstract
Abstract: The synthesis of two 7-carboxyindolylglycines is described as putative metabotropic glutamate receptor (mGluR) antagonists, employing glycine cation equivalents in the key steps.
Notes
The indole amino acids 2 and 3 were evaluated for PI hydrolysis activity in AV-12 cells transfected with human mGluR1α or mGluR5a receptors and were found to be inactive up to concentrations of 100μM.