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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 24
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Original Articles

In Situ Activated Zinc-Copper Couple for the Preparation of a Key Intermediate in the Synthesis of Dideoxyinosine (DDI)

John L. Dillon Process Exploration Laboratories, Technical Operations Development, Bristol-Myers Squibb Company, P. O. Box 4755, Syracuse, New York, 13221-4755
Pages 4367-4371 | Received 05 Jun 1997, Published online: 22 Aug 2006
 
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Abstract

Abstract: Didehydrodideoxyadenosine 2 is a key intermediate in the synthesis of the AIDS drug dideoxyinosine. An improved method for the preparation of this compound using in situ activated zinc-copper couple is described.

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