N-tert-Butoxycarbonyl (BOC) Deprotection Using Boron Trifluoride Etherate

Emily F. Evans Department of Chemistry, University of York, Heslington, York, YO1 5DD, UK

Norman J. Lewis SmithKline Beecham Pharmaceuticals, Leigh, Tonbridge, Kent, TN11 9AN, UK

Isabelle Kapfer Department of Chemistry, University of York, Heslington, York, YO1 5DD, UK

Gregor Macdonald Department of Chemistry, University of York, Heslington, York, YO1 5DD, UK

Richard J. K. Taylor Department of Chemistry, University of York, Heslington, York, YO1 5DD, UK

Abstract

A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOC) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

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N-tert-Butoxycarbonyl (BOC) Deprotection Using Boron Trifluoride Etherate

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N-tert-Butoxycarbonyl (BOC) Deprotection Using Boron Trifluoride Etherate

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