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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 18
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Original Articles

A Convenient Synthesis of 3-Arylbutanolides and 3-Arylbutenolides

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Pages 3305-3315 | Received 25 Mar 1998, Published online: 22 Aug 2006
 

Abstract

A series of 3-aryl-substituted butenolides and butanolides has been prepared in a common short synthetic sequence from the corresponding aryl aldehydes. The 3-arylbutanolides are prepared by cyclisation of 3-aryl-3-cyano-1-propanols, obtained by selective reduction of 3-aryl-3-cyanopropionate esters, and are converted to 3-arylbutenolides by a sulfoxide or selenoxide elimination reaction.

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