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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 24
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Original Articles

An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

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Pages 4525-4530 | Received 08 Jun 1998, Published online: 22 Aug 2006
 

Abstract

An efficient, two-step syntesis of the title compound 3 in 61% overall yield is presented. The synthesis involves hydrazine removal of the N-phthalimide protecting group of α-phthalimido-o-toluic acid (6), followed by N-Fmoc formation with (9-fluorenylmethyl)succinimidyl carbonate.

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