A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position: Synthetic Communications: Vol 28, No 24

Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 28, 1998 - Issue 24

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Abstract

Treatment of 2-methoxyacetamidobenzonitriles or 2-chloroacetamidobenzonitrile with UHP and K₂CO₃ provides a convenient route to 2-methoxymethyl-or 2-chloromethylquinazolin-4(3H)-ones. In addition, demethylation of 2-methoxymethylquinazolin-4(3H)-ones with 48% HBr gives 2-hydroxymethylquinazolin-4(3H)-ones.

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A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position

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A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position

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