A Convenient One-Pot Synthesis of 1,2-Aminoalcohols

J. Howarth School of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland

D. G. Lloyd School of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland

P. McCormac School of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland

Abstract

We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.

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A Convenient One-Pot Synthesis of 1,2-Aminoalcohols

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A Convenient One-Pot Synthesis of 1,2-Aminoalcohols

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