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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 19
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Original Articles

An Effective Synthetic Route to Ef5

Ian R. Baird Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1 Fax: E-mail: [email protected]; Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada, V5Z 1L3
,
Kirsten A. Skov Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada, V5Z 1L3
,
Brian R.James Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1 Fax: E-mail: [email protected]
,
Steven J. Rettig Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1 Fax: E-mail: [email protected]
&
Cameron J. Koch Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104-6072, U.S.A.
Pages 3701-3709 | Received 16 Apr 1998, Published online: 22 Aug 2006
 
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Abstract

EF5 (a 2-nitroimidazole containing an N-(pentafluoropropyl) acetamide substituent) is a very sensitive probe for quantifying the amount of hypoxia within cells; a much improved, short step, synthetic procedure is described for EF5, whose X-ray structure is also presented.

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