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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 20
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Original Articles

The Practical Use of a Glycine Anion Equivalent for the Preparation of 3-Carboxy-1,2-Dihydro-1-Oxoisoquinoline

Nicolas Gautier Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France
&
Robert H. Dodd Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France
Pages 3769-3777 | Received 27 Apr 1998, Published online: 23 Aug 2006
 
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Abstract

Reaction of the dianion derived from N-Cbz-glycine ethyl ester with 2-carboxybenzaldehyde gave the 2-(phthalidyl)glycinate derivative 8 as the major product. Successive treatment of the latter with LiOH and CF3CO2H/CF3SO3H afforded the title compound in good overall yield.

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