Study on the Intramolecular Mannich Reaction of 4-Amino-3-aryl-2,3-dihydrogen-5-mercapto-1,2,4-triazoles

Shi Haijian Department of Chemistry, Anhui Normal University, Wuhu, Anhui, 241000, P.R.China

Wang Zhongyi Department of Chemistry, Anhui Normal University, Wuhu, Anhui, 241000, P.R.China; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P.R.China

Shi Haoxin Department of Chemistry, Anhui Normal University, Wuhu, Anhui, 241000, P.R.China

Abstract

Seventeen novel fused heterocycles have been prepared by the intramolecular Mannich reaction of 4-amino-3-aryl-5-mercapto-1,2,4-triazole with aldehydes in the presence of acid, Yield: 32 ∼ 90%. These compounds were screened for their antimicrobial activities.

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Study on the Intramolecular Mannich Reaction of 4-Amino-3-aryl-2,3-dihydrogen-5-mercapto-1,2,4-triazoles

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Study on the Intramolecular Mannich Reaction of 4-Amino-3-aryl-2,3-dihydrogen-5-mercapto-1,2,4-triazoles

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