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Abstract
A coupling reagent, diethyl chlorophosphate (DECP) 2, was reacted with 2-(2-amino-4-thiazolyl)-2-syn-alkoxyiminoacetic acid 1 to give an active ester intermediate 3.
Notes
According to this patent, in general about fifteen hours is required for completion of 7- aminocephalosporanic acid derivatives by the method of HOBT-DCC.