The Reaction of Organometallic Compounds with the Weinreb Amide of 3,7-Dichloroquinoline-8-carboxylic Acid

Abstract

The reaction of Grignard or organolithium reagents with the Weinreb amide of 3,7-dichloroquinoline-8-carboxylic acid afforded 2-substituted derivatives 5 via nucleophilic substitution reaction with hydride transfer as the major product instead of the normally expected ketone derivatives 4.