Regio- and Stereoselective Alkoxycarbonylmethylenation of Partially Saturated Heterobicyclic Compounds: First Synthesis of 2-Substituted Quinazoline-8-acetic Acid Esters

Albrecht Zumbrunn# Novartis Crop Protection AG, Fungicides Research, R-1047.218, Schwarzwaldallee 211, CH-4002, Basel, Switzerland

Clemens Lamberth Novartis Crop Protection AG, Fungicides Research, R-1047.218, Schwarzwaldallee 211, CH-4002, Basel, Switzerland

Fritz Schaub Novartis Crop Protection AG, Fungicides Research, R-1047.218, Schwarzwaldallee 211, CH-4002, Basel, Switzerland

Abstract

The three-step synthesis of 2-substituted quinazol-8-yl acetates is described, introducing a completely new method for the regio- and stereoselective alkoxycarbonylmethylenation of tetrahydroquinazolines.

^# Novartis Crop Protection Ltd., Research Department, 975 California Avenue, Palo Alto, CA 94303, USA.

Notes

^# Novartis Crop Protection Ltd., Research Department, 975 California Avenue, Palo Alto, CA 94303, USA.

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Regio- and Stereoselective Alkoxycarbonylmethylenation of Partially Saturated Heterobicyclic Compounds: First Synthesis of 2-Substituted Quinazoline-8-acetic Acid Esters

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Regio- and Stereoselective Alkoxycarbonylmethylenation of Partially Saturated Heterobicyclic Compounds: First Synthesis of 2-Substituted Quinazoline-8-acetic Acid Esters

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