A Facile Isomerization Procedure for the Access to Thermodynamic Silyl Enol Ethers

Abstract

Efficient access to thermodynamically favoured silyl enol ethers deriving from α,α′-dienolizable ketones was produced via easy-made NEt₃HCl-mediated isomerization of a regioisomeric mixture of O-silylated products.

^† deceased on 7 may 1997

§ Present adress: Laboratoire de Synthése Organique, associé au CNRS, Université du Maine, Avenue Olivier Messiaen, B.P. 9 F-72085 Le Mans (France)

Notes

^† deceased on 7 may 1997

§ Present adress: Laboratoire de Synthése Organique, associé au CNRS, Université du Maine, Avenue Olivier Messiaen, B.P. 9 F-72085 Le Mans (France)

These procedures use the heating of trialkylsilyl enol ethers in a solvent, in the presence of an ammonium salt