Synthesis of 2-Acyltetrahydroisoquinolines and 2-Acyl-1,2,3,4-tetrahydro-1,2-benzothiazine-1,1-diones by Electrophilic Substitution Reactions of N-Acyl-2-Phenylethylamines

Abstract

1-Substituted- 5, 1,5-substituted 7,8-dioxygenated-2-acyltetrahydroisoquino-lines 10 and 2-acyl-1,2,3,4-tetrahydro-1,2-benzothiazine-1,1-diones 12 has been obtained by the reaction of N-acyl-2-phenylethylamines with aldehydes or chlorosulfonic acid as a result of an electrophilic hydroxyalkylation and chlorosulfonation of the aromatic ring.