Practical Preparation and Reactivity of Valuable Functionalized Cyclic α,α'-Ketodiesters

Abstract

A study including some aspect of the reactivity and the preparation of cyclic ketodiesters from the condensation of dimethyl 3-oxoglutarate 1 with various bishalomethyl derivatives 2—6 using K₂CO₃ in THF is described.

Notes

This limitation seems to be the consequence of the high sensitivity of 13, which suffered extensive degradation under the reaction conditions.

A detailled study of this anionic domino reaction is currently underway in our laboratory.

For previous preparation of 15 (yields from 24 to 60%), see ref. 6b.