Reductions of Organic Functional Groups Using NaBH₄ OR NaBH₄/LiCl in Diglyme at 125 TO 162 °C

Abstract

Reduction of nitro, amide, carboxylate, ester and nitrile functional groups to -NH₂, -CH₂NH₂, -CH₂OH, -CH₂OH and -CH₂NCHPh, respectively were achieved using NaBH₄ or NaBH₄/LiCl in diglyme at 125—162 °C. This greatly extends the range of functional group types which can be considered generally reducible by borohydride.