A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with Methyl Bromoacetate and Bromoacetonitrile

Juraj Bernát Department of Organic Chemistry, P.J. Šafarik University, SK-041 67, Košice, Slovakia

Igor Chomča Department of Organic Chemistry, P.J. Šafarik University, SK-041 67, Košice, Slovakia

Pavol Kristian Department of Organic Chemistry, P.J. Šafarik University, SK-041 67, Košice, Slovakia

Gundula Voss Department of Organic Chemistry, Bayreuth University, D-954 47, Bayreuth, Germany

Abstract

A convenient method has been devised for the preparation of the spirodihydro-acridinethiazolines 5a-j by the treatment of thioureas 3a-e with methyl bromoacetate and bromoacetonitrile via non-isolable isothioureas 4a-j and their subsequent cyclization with methanolic sodium methoxide.

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A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with Methyl Bromoacetate and Bromoacetonitrile

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A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with Methyl Bromoacetate and Bromoacetonitrile

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