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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 22
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Original Articles

Synthesis of 4-Arylidene-2-Phenyloxazol-5-Ones Using 1:1 Mixture of Al2O3 -H3BO3

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Pages 4187-4191 | Received 01 Jun 1998, Published online: 11 Mar 2009
 

Abstract

Cyclodehydration-condensation of hippuric acid and arylaldehydes have been carried out using a 1:1 mixture of Al2O3-H3BO3 in the presence of stoichiometric quantity of acetic anhydride to give the target compound in good yield. This procedure can be used to synthesize the 4-alkylidene analogs also.

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