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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 23
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Original Articles

A Facile and Practical Synthesis of Capsazepine, a Vanilloid Receptor Antagonist

Jeewoo Lee Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Shinlim-Dong, Kwanak-Ku, Seoul, 151-742, Korea
&
Jiyoun Lee Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Shinlim-Dong, Kwanak-Ku, Seoul, 151-742, Korea
Pages 4127-4140 | Received 16 Feb 1999, Published online: 17 Sep 2007
 
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Abstract

A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist, has been accomplished from isovanillin in 8 steps via an efficient intramolecular Mannich cyclization.

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