Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 23
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Original Articles

A Short Stereoselective Synthesis of a Cyclopropyl Analog of γ-Aminobutyric acid (GABA)

Pages 4261-4268 | Received 24 Feb 1999, Accepted 26 Apr 1999, Published online: 17 Sep 2007
 

Abstract

An efficient synthesis of (S,S)-2-(aminomethyl) cyclopropane carboxylic acid has been achieved in 7 steps (38% overall yield) starting from commercially available cinnamyl alcohol. The synthesis involves initial stereoselective formation of the functionalized cyclopropane derivative 5 and its further transformation to the desired product.

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