A Short, Convenient Synthesis of 2-Arylglycidates via Aryl-Grignard Addition to an α-Bromopyruvate

Abstract

A simple procedure has been developed for the preparation of a series of 2-arylglycidates required for herbicidal evaluation. Treatment of the α-bromopyruvate 5 with various aryl Grignard reagents at low temperature gave directly the glycidates 4. Saponification of these then afforded the desired sodium salts 7.