Solid Phase Acylation of Phosphonoacetates Synthesis of β-Keto Phosphonates from Polymer Bound Phosphonoacetate

Abstract

Solid phase synthesis of phase synthesis of β-keto phosphonates, via acylation reaction of polymer bound phosphoacetate with carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by cleavage of resin with concomitant decarboxylation, is described.