Enzymatic Method of Preparation of Opticallly Active Trans-2-Amtno Cyclohexanol Derivatives

A. Ursini Glaxo Wellcome Research Centre, Chemical Development Department, Via A. Fleming, 4, Verona, Italy

P. Maragni Glaxo Wellcome Research Centre, Chemical Development Department, Via A. Fleming, 4, Verona, Italy

C. Bismara Glaxo Wellcome Research Centre, Chemical Development Department, Via A. Fleming, 4, Verona, Italy

B. Tamburini Glaxo Wellcome Research Centre, Chemical Development Department, Via A. Fleming, 4, Verona, Italy

Abstract

Supported Lipase Amano PS-D catalyzes the resolution of (±)-trans-2-tert butoxycarbonyl amino cyclohexanol by a selective acylation reaction. Using the supported enzyme gave a much faster reaction compared to existing methodology on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Enzymatic Method of Preparation of Opticallly Active Trans-2-Amtno Cyclohexanol Derivatives

Information for

Open access

Opportunities

Help and information

Enzymatic Method of Preparation of Opticallly Active Trans-2-Amtno Cyclohexanol Derivatives

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature