Acetyl Bromide-Alcohols as Convenient Reaction Systems for: a) Removal of N-tert-Boc, N-Cbz And N-Ac Protective Groups, b) Esterifications and Transesterifications, c) Debenzylation of Aryl-O-Benzyl Ethers

Abstract

Hydrogen bromide generated in situ by the addition of acetyl bromide to alcohols is a useful reagent for esterifications and transesterifications; N-tert-Boc, N-Cbz, and N-Ac deprotections; and debenzylation reactions.