Improved Procedures For Large Scale Preparation Of 6- and 7-Oxy-Substituted Isoquinolines and A Convenient Work-Up Protocol For Titanium Supported Reactions

Ralf Kucznierz Chemical Research Department, Boehringer Mannheim, GmbH, D-68298, Mannheim, Germany

Joachim Dickhaut Chemical Research Department, Boehringer Mannheim, GmbH, D-68298, Mannheim, Germany

Herbert Leinert Chemical Research Department, Boehringer Mannheim, GmbH, D-68298, Mannheim, Germany

Wolfgang von der Saal Chemical Research Department, Boehringer Mannheim, GmbH, D-68298, Mannheim, Germany

Abstract

Improved procedures for large scale preparation of oxy-substituted isoquinoiines are reported. Moreover, a simple and convenient protocol for alkaline work-up of titanium containing reaction mixtures is given, which is expected to be of general interest even for reactions on a technical scale.

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Improved Procedures For Large Scale Preparation Of 6- and 7-Oxy-Substituted Isoquinolines and A Convenient Work-Up Protocol For Titanium Supported Reactions

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Improved Procedures For Large Scale Preparation Of 6- and 7-Oxy-Substituted Isoquinolines and A Convenient Work-Up Protocol For Titanium Supported Reactions

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