Optical Resolution in two Immiscible Solvents in the Presence of an Intermediate Solvent. Optical Resolution of N-Methyl-Amphetamine by O,O′-Dibenzoyl-R,R-Tartaric Acid in Dichloroethane-Water-Methanol Solvent System

Abstract

A new optical resolution method was developed by the use of a two phase three component solvent system and demonstrated on the example of the resolution of the N-methyl-amphetamine with O,O′-dibenzoyl-R,R-tartaric acid. By adding methanol as an intermediate solvent to the two phase water-dichloroethane solvent system the solubility and the optical purity of the precipitated salt can be adjusted in wide ranges. By this way a highly efficient one step resolution process can be accomplished.