Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 24
Submit an article Journal homepage
69
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Easy Access to Both Enantiomers of C7-C12 Segment of Epothilones

Shinji TanimoriDepartment of Applied Biochemistry, College of Agriculture, Osaka Prefecture University, 1-1 Gakuen-cho Sakai, Osaka, 599-8531, Japan
,
Koichi TanimotoDepartment of Applied Biochemistry, College of Agriculture, Osaka Prefecture University, 1-1 Gakuen-cho Sakai, Osaka, 599-8531, Japan
&
Mitsunori KirihataDepartment of Applied Biochemistry, College of Agriculture, Osaka Prefecture University, 1-1 Gakuen-cho Sakai, Osaka, 599-8531, Japan
Pages 4353-4360 | Received 18 Feb 1999, Published online: 25 Sep 2007
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Both enantiomers of the C7-C12 segment (5 and 6) of epothilones A and B (1 and 2) were effectively synthesized starting from the methyl (R)- and (S)-hydroxy-2-methylpropionates (3 and 4) using the Grignard cross-coupling reaction mediated by cuprous (I) salts in three steps.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.